This Week in PLoS Medicine: Publication bias; CD4 count in AIDS; Health Systems Guidance

Four new articles were published this week in PLoS Medicine, including the end to a series on Health Systems Guidance.

A comparison by Erick Turner and colleagues of data held by the US Food and Drug Administration (FDA) with data from journal reports of clinical trials reveals publication bias for antipsychotics.

Using data from the Collaboration of Observational HIV Epidemiological Research Europe, Jim Young and colleagues show that in successfully treated patients the risk of a new AIDS event or death follows a CD4 cell count gradient in patients with viral suppression.

In the third paper in a three-part series on health systems guidance, Simon Lewin and colleagues explore the challenge of assessing how much confidence to place in evidence on health systems interventions.

David Peters and Sara Bennett provide a critical perspective on a three-part series on health systems guidance that examines how evidence should be used to strengthen health systems and improve the delivery of global health interventions.

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