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This Week in PLOS Medicine: Genotyping TB; NSAIDs & cardiac risk; mHealth

Michael Morris General

Image Credit: Milica Sekulic

Four new articles published this week in PLOS Medicine, including a Perspective on new research into NSAIDs.

In an outbreak investigation of Mycobacterium tuberculosis comparing whole genome sequencing (WGS) with traditional genotyping, Stefan Niemann and colleagues found that classical genotyping falsely clustered some strains and WGS better reflected contact tracing.

Patricia McGettigan and David Henry find that, although some non-steroidal anti-inflammatory drugs (NSAIDs) such as diclofenac are known to increase cardiovascular risk, diclofenac is included on 74 countries’ essential medicine lists and was the most commonly used NSAID in the 15 countries they evaluated.

K. Srinath Reddy and Ambuj Roy discuss the Research Article by Patricia McGettigan and David Henry about the continued use of NSAIDs associated with increased risk of cardiovascular disease, including the mechanisms of increased risk, probable reasons for ongoing use, and next steps.

Mark Tomlinson and colleagues question whether there is sufficient evidence on implementation and effectiveness to match the wide enthusiasm for mHealth interventions, and propose a global strategy to determine needed evidence to support mHealth scale-up.

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